| 1. Round | 13/03/2022 | PAOK Saloniki | - | PAS Giannina | 1:0 |  |
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| 5. Round | 17/04/2022 | Aris Saloniki | - | PAOK Saloniki | 1:0 | |
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| 6. Round | 01/05/2022 | PAOK Saloniki | - | AEK Athen | 1:1 | ||||
| 4. Round | 04/05/2022 | PAOK Saloniki | - | Olympiakos Piraeus | 1:2 | ||||
| 7. Round | 08/05/2022 | PAS Giannina | - | PAOK Saloniki | 1:0 | ||||
| 8. Round | 11/05/2022 | PAOK Saloniki | - | Aris Saloniki | 0:1 | ||||
| 9. Round | 14/05/2022 | Olympiakos Piraeus | - | PAOK Saloniki | 1:1 |  |
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| 10. Round | 17/05/2022 | PAOK Saloniki | - | Panathinaikos | 2:0 |
Portugal