| 4. Round | 21/08/2021 | FC Zürich | - | Grasshopper Club Zürich | 2:1 | ||||
| 5. Round | 29/08/2021 | Grasshopper Club Zürich | - | Servette FC | 1:1 | ||||
| 7. Round | 23/09/2021 | FC Lugano | - | Grasshopper Club Zürich | 1:1 | ||||
| 8. Round | 26/09/2021 | Grasshopper Club Zürich | - | FC Sion | 3:1 | ||||
| 12. Round | 31/10/2021 | FC Sion | - | Grasshopper Club Zürich | 1:3 |  |
|||
| 13. Round | 06/11/2021 | Grasshopper Club Zürich | - | BSC Young Boys | 1:1 | ||||
| 18. Round | 19/12/2021 | FC Basel 1893 | - | Grasshopper Club Zürich | 2:2 |
Switzerland