| 1. Round | 17/07/2021 | Newell's Old Boys | - | Talleres de Córdoba | 3:2 | ||||
| 2. Round | 27/07/2021 | Argentinos Juniors | - | Newell's Old Boys | 1:0 | ||||
| 21. Round | 21/11/2021 | Arsenal de Sarandí | - | Newell's Old Boys | 3:1 | ||||
| 22. Round | 24/11/2021 | Newell's Old Boys | - | Central Córdoba SdE | 1:0 | ||||
| 23. Round | 30/11/2021 | Boca Juniors | - | Newell's Old Boys | 0:0 | ||||
| 24. Round | 07/12/2021 | Newell's Old Boys | - | Banfield | 0:0 |  |
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| 25. Round | 12/12/2021 | San Lorenzo | - | Newell's Old Boys | 3:2 | |
Argentina
USA