| 1. Round | 17/01/2021 | Atlético Junior | - | Independiente Medellín | 1:0 | ||||
| 2. Round | 25/01/2021 | Once Caldas | - | Atlético Junior | 1:2 |  |
|||
| 3. Round | 31/01/2021 | Atlético Junior | - | América de Cali | 2:1 | |
|||
| 4. Round | 03/02/2021 | La Equidad | - | Atlético Junior | 1:0 | ||||
| 9. Round | 24/02/2021 | Atlético Junior | - | Millonarios | 2:0 | ||||
| 10. Round | 28/02/2021 | Patriotas FC | - | Atlético Junior | 1:0 | ||||
| 11. Round | 06/03/2021 | Atlético Junior | - | Atlético Bucaramanga | 1:1 | |
|||
| 12. Round | 15/03/2021 | Atlético Nacional | - | Atlético Junior | 1:0 | ||||
| 13. Round | 20/03/2021 | Atlético Junior | - | Deportivo Pereira | 3:0 | ||||
| 14. Round | 24/03/2021 | Deportes Tolima | - | Atlético Junior | 0:1 | ||||
| 15. Round | 27/03/2021 | Atlético Junior | - | Santa Fe | 1:1 |  |
|||
| 17. Round | 05/04/2021 | Atlético Junior | - | Águilas Doradas | 0:0 | ||||
| 18. Round | 11/04/2021 | Deportivo Pasto | - | Atlético Junior | 0:0 |
Colombia