| 1. Round | 23/01/2022 | Atlético Junior | - | Patriotas FC | 3:1 | ||||
| 2. Round | 27/01/2022 | Atlético Nacional | - | Atlético Junior | 3:1 | ||||
| 3. Round | 29/01/2022 | Atlético Junior | - | La Equidad | 1:0 |  |
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| 4. Round | 03/02/2022 | Santa Fe | - | Atlético Junior | 2:1 |  |
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| 5. Round | 07/02/2022 | Atlético Junior | - | Águilas Doradas | 2:1 | ||||
| 6. Round | 12/02/2022 | Once Caldas | - | Atlético Junior | 1:0 | ||||
| 7. Round | 17/02/2022 | Independiente Medellín | - | Atlético Junior | 2:0 | |
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| 8. Round | 20/02/2022 | Atlético Junior | - | América de Cali | 1:0 | ||||
| 9. Round | 26/02/2022 | Deportes Tolima | - | Atlético Junior | 0:2 | ||||
| 10. Round | 05/03/2022 | Atlético Junior | - | Unión Magdalena | 3:1 | ||||
| 12. Round | 25/03/2022 | Atlético Junior | - | Deportivo Pasto | 1:1 | |
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| 13. Round | 31/03/2022 | Millonarios | - | Atlético Junior | 1:0 | ||||
| 14. Round | 03/04/2022 | Atlético Junior | - | Alianza Petrolera | 3:1 | ||||
| 15. Round | 10/04/2022 | Deportivo Cali | - | Atlético Junior | 1:1 | ||||
| 16. Round | 17/04/2022 | Atlético Junior | - | Atlético Bucaramanga | 2:0 | ||||
| 17. Round | 24/04/2022 | Unión Magdalena | - | Atlético Junior | 0:3 dec. | |
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| 19. Round | 08/05/2022 | Cortuluá | - | Atlético Junior | 1:0 | |
Colombia