4. Round | 08/02/2022 | Club León | - | Cruz Azul | 0:1 | ||||
5. Round | 13/02/2022 | Pumas UNAM | - | Club León | 2:1 | ||||
9. Round | 05/03/2022 | FC Juárez | - | Club León | 0:1 | ||||
10. Round | 12/03/2022 | Club León | - | UANL Tigres | 0:3 | ||||
11. Round | 21/03/2022 | Mazatlán FC | - | Club León | 1:2 | ||||
12. Round | 03/04/2022 | Club León | - | Gallos Blancos | 1:1 | ||||
13. Round | 09/04/2022 | Atlético San Luis | - | Club León | 2:0 |