| 1. Round | 11/02/2022 | Arsenal de Sarandí | - | Rosario Central | 1:1 | ||||
| 2. Round | 15/02/2022 | Rosario Central | - | Vélez Sarsfield | 1:0 | ||||
| 3. Round | 20/02/2022 | Boca Juniors | - | Rosario Central | 2:1 | ||||
| 4. Round | 26/02/2022 | Rosario Central | - | Godoy Cruz | 1:2 | ||||
| 5. Round | 04/03/2022 | Central Córdoba SdE | - | Rosario Central | 0:1 |  |
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| 6. Round | 12/03/2022 | Rosario Central | - | Barracas Central | 1:3 | ||||
| 7. Round | 20/03/2022 | Rosario Central | - | Newell's Old Boys | 0:1 | |
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| 8. Round | 04/04/2022 | Tigre | - | Rosario Central | 2:0 | ||||
| 9. Round | 09/04/2022 | Rosario Central | - | Colón de Santa Fe | 2:2 | ||||
| 10. Round | 15/04/2022 | Aldosivi | - | Rosario Central | 1:0 | ||||
| 11. Round | 20/04/2022 | Lanús | - | Rosario Central | 3:1 | ||||
| 12. Round | 23/04/2022 | Rosario Central | - | Independiente | 3:0 | ||||
| 13. Round | 03/05/2022 | Huracán | - | Rosario Central | 2:1 | |
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| 14. Round | 07/05/2022 | Rosario Central | - | Estudiantes | 3:1 |
Argentina