| 3. Round | 29/01/2022 | Puebla FC | - | Club Tijuana | 3:1 | ||||
| 11. Round | 21/03/2022 | Club Tijuana | - | FC Juárez | 1:0 | ||||
| 12. Round | 04/04/2022 | UANL Tigres | - | Club Tijuana | 2:0 | ||||
| 9. Round | 07/04/2022 | Club Tijuana | - | Atlético San Luis | 1:1 | ||||
| 13. Round | 12/04/2022 | CF Pachuca | - | Club Tijuana | 0:0 |  |
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| 14. Round | 16/04/2022 | Club Tijuana | - | CF América | 1:3 | ||||
| 15. Round | 20/04/2022 | Deportivo Guadalajara | - | Club Tijuana | 2:1 |
Mexico