| 21. Round | 13/02/2022 | FC Luzern | - | FC Sion | 1:0 | ||||
| 22. Round | 20/02/2022 | FC Sion | - | FC Zürich | 1:1 | ||||
| 23. Round | 26/02/2022 | BSC Young Boys | - | FC Sion | 3:1 | ||||
| 24. Round | 02/03/2022 | FC Sion | - | FC Lausanne-Sport | 1:0 | ||||
| 25. Round | 06/03/2022 | FC St. Gallen | - | FC Sion | 1:1 |  |
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| 26. Round | 12/03/2022 | FC Sion | - | FC Lugano | 0:3 | |
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| 27. Round | 20/03/2022 | Servette FC | - | FC Sion | 2:1 | |
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| 28. Round | 02/04/2022 | FC Sion | - | FC St. Gallen | 0:3 | |
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| 31. Round | 23/04/2022 | FC Zürich | - | FC Sion | 5:1 |
France
