| 6. Round | 21/10/2017 | Sampdoria [Youth] | - | Sassuolo Calcio [Youth] | 1:1 |  |
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| 7. Round | 29/10/2017 | AC Milan [Youth] | - | Sampdoria [Youth] | 2:0 | ||||
| 8. Round | 04/11/2017 | Sampdoria [Youth] | - | Bologna FC [Youth] | 0:2 | ||||
| 11. Round | 04/12/2017 | Genoa CFC [Youth] | - | Sampdoria [Youth] | 1:3 | ||||
| 12. Round | 09/12/2017 | Chievo Verona [Youth] | - | Sampdoria [Youth] | 1:1 | ||||
| 13. Round | 16/12/2017 | Sampdoria [Youth] | - | Lazio Roma [Youth] | 3:1 | ||||
| 14. Round | 22/12/2017 | Juventus [Youth] | - | Sampdoria [Youth] | 1:0 | ||||
| 15. Round | 13/01/2018 | Sampdoria [Youth] | - | SSC Napoli [Youth] | 1:1 | ||||
| 17. Round | 27/01/2018 | Sampdoria [Youth] | - | ACF Fiorentina [Youth] | 1:2 | ||||
| 18. Round | 03/02/2018 | Atalanta [Youth] | - | Sampdoria [Youth] | 3:1 | ||||
| 20. Round | 16/02/2018 | Inter [Youth] | - | Sampdoria [Youth] | 1:0 | ||||
| 23. Round | 10/03/2018 | Bologna FC [Youth] | - | Sampdoria [Youth] | 1:2 | ||||
| 26. Round | 21/04/2018 | Sampdoria [Youth] | - | Genoa CFC [Youth] | 2:2 | ||||
| 28. Round | 05/05/2018 | Lazio Roma [Youth] | - | Sampdoria [Youth] | 0:1 | ||||
| 29. Round | 13/05/2018 | Sampdoria [Youth] | - | Juventus [Youth] | 0:3 |
Portugal