| 1. Round | 18/09/2020 | Bayern München | - | FC Schalke 04 | 8:0 | ||||
| 2. Round | 26/09/2020 | FC Schalke 04 | - | Werder Bremen | 1:3 |  |
|||
| 3. Round | 03/10/2020 | RB Leipzig | - | FC Schalke 04 | 4:0 | ||||
| 4. Round | 18/10/2020 | FC Schalke 04 | - | 1. FC Union Berlin | 1:1 |  |
|
||
| 5. Round | 24/10/2020 | Borussia Dortmund | - | FC Schalke 04 | 3:0 | ||||
| 6. Round | 30/10/2020 | FC Schalke 04 | - | VfB Stuttgart | 1:1 | ||||
| 7. Round | 07/11/2020 | 1. FSV Mainz 05 | - | FC Schalke 04 | 2:2 | ||||
| 8. Round | 21/11/2020 | FC Schalke 04 | - | VfL Wolfsburg | 0:2 | ||||
| 27. Round | 03/04/2021 | Bayer Leverkusen | - | FC Schalke 04 | 2:1 | ||||
| 28. Round | 11/04/2021 | FC Schalke 04 | - | FC Augsburg | 1:0 | ||||
| 29. Round | 17/04/2021 | SC Freiburg | - | FC Schalke 04 | 4:0 | ||||
| 30. Round | 20/04/2021 | Arminia Bielefeld | - | FC Schalke 04 | 1:0 | ||||
| 31. Round | 12/05/2021 | FC Schalke 04 | - | Hertha BSC | 1:2 | ||||
| 33. Round | 15/05/2021 | FC Schalke 04 | - | Eintracht Frankfurt | 4:3 | ||||
| 34. Round | 22/05/2021 | 1. FC Köln | - | FC Schalke 04 | 1:0 |
Portugal