| 1. Round | 10/01/2022 | Deportivo Guadalajara | - | Mazatlán FC | 3:0 | ||||
| 3. Round | 22/01/2022 | Mazatlán FC | - | Deportivo Toluca | 1:2 |  |
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| 5. Round | 12/02/2022 | Mazatlán FC | - | Club Tijuana | 2:0 | ||||
| 2. Round | 17/02/2022 | Mazatlán FC | - | CF América | 2:1 |  |
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| 6. Round | 19/02/2022 | Gallos Blancos | - | Mazatlán FC | 2:0 | ||||
| 7. Round | 25/02/2022 | CF Pachuca | - | Mazatlán FC | 3:1 | ||||
| 8. Round | 02/03/2022 | Mazatlán FC | - | Club Necaxa | 0:0 | ||||
| 10. Round | 12/03/2022 | CF Monterrey | - | Mazatlán FC | 2:1 | ||||
| 11. Round | 21/03/2022 | Mazatlán FC | - | Club León | 1:2 | ||||
| 9. Round | 26/03/2022 | Pumas UNAM | - | Mazatlán FC | 1:1 | ||||
| 12. Round | 02/04/2022 | Atlético San Luis | - | Mazatlán FC | 1:0 | ||||
| 13. Round | 09/04/2022 | Mazatlán FC | - | Cruz Azul | 1:1 | ||||
| 14. Round | 15/04/2022 | Atlas Guadalajara | - | Mazatlán FC | 1:2 | |
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| 15. Round | 20/04/2022 | Mazatlán FC | - | Santos Laguna | 1:0 | |
Argentina