| 9. Round | 23/10/2021 | Arminia Bielefeld | - | Borussia Dortmund | 1:3 | ||||
| 18. Round | 08/01/2022 | SC Freiburg | - | Arminia Bielefeld | 2:2 | ||||
| 19. Round | 16/01/2022 | Arminia Bielefeld | - | SpVgg Greuther Fürth | 2:2 |  |
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| 21. Round | 05/02/2022 | Arminia Bielefeld | - | Bor. Mönchengladbach | 1:1 | ||||
| 22. Round | 13/02/2022 | 1899 Hoffenheim | - | Arminia Bielefeld | 2:0 | ||||
| 23. Round | 19/02/2022 | Arminia Bielefeld | - | 1. FC Union Berlin | 1:0 | ||||
| 24. Round | 26/02/2022 | Bayer Leverkusen | - | Arminia Bielefeld | 3:0 | ||||
| 25. Round | 04/03/2022 | Arminia Bielefeld | - | FC Augsburg | 0:1 | ||||
| 30. Round | 17/04/2022 | Arminia Bielefeld | - | Bayern München | 0:3 | ||||
| 31. Round | 23/04/2022 | 1. FC Köln | - | Arminia Bielefeld | 3:1 | ||||
| 32. Round | 30/04/2022 | Arminia Bielefeld | - | Hertha BSC | 1:1 | ||||
| 33. Round | 06/05/2022 | VfL Bochum | - | Arminia Bielefeld | 2:1 | ||||
| 34. Round | 14/05/2022 | Arminia Bielefeld | - | RB Leipzig | 1:1 |
Portugal