| 2. Round | 14/01/2022 | Club Necaxa [U18] | - | CF Monterrey [U18] | 1:4 | ||||
| 3. Round | 23/01/2022 | Santos Laguna [U18] | - | Club Necaxa [U18] | 1:2 | ||||
| 6. Round | 18/02/2022 | Club Tijuana [U18] | - | Club Necaxa [U18] | 3:2 | ||||
| 7. Round | 25/02/2022 | Club Necaxa [U18] | - | Club León [U18] | 2:0 | ||||
| 8. Round | 01/03/2022 | Mazatlán FC [U18] | - | Club Necaxa [U18] | 2:0 |  |
|||
| 10. Round | 11/03/2022 | Club Necaxa [U18] | - | Gallos Blancos [U18] | 2:0 | ||||
| 11. Round | 19/03/2022 | Pumas UNAM [U18] | - | Club Necaxa [U18] | 0:0 | ||||
| 14. Round | 15/04/2022 | Club Necaxa [U18] | - | Atlético San Luis [U18] | 1:2 | ||||
| 15. Round | 19/04/2022 | Club Necaxa [U18] | - | UANL Tigres [U18] | 2:0 |  |
|||
| 16. Round | 22/04/2022 | Puebla FC [U18] | - | Club Necaxa [U18] | 1:4 | ||||
| 17. Round | 29/04/2022 | Club Necaxa [U18] | - | Deportivo Guadalajara [U18] | 1:3 | |
Mexico