| 2. Round | 31/07/2021 | CF América [U18] | - | Club Necaxa [U18] | 2:3 |  |
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| 5. Round | 17/08/2021 | Club Necaxa [U18] | - | Pumas UNAM [U18] | 4:2 | ||||
| 6. Round | 22/08/2021 | Club Necaxa [U18] | - | FC Juárez [U18] | 3:2 | ||||
| 7. Round | 28/08/2021 | Deportivo Guadalajara [U18] | - | Club Necaxa [U18] | 1:2 | ||||
| 8. Round | 12/09/2021 | Gallos Blancos [U18] | - | Club Necaxa [U18] | 1:1 | ||||
| 9. Round | 17/09/2021 | Club Necaxa [U18] | - | Atlas Guadalajara [U18] | 1:0 | ||||
| 10. Round | 23/09/2021 | CF Pachuca [U18] | - | Club Necaxa [U18] | 5:1 | ||||
| 11. Round | 28/09/2021 | Club Necaxa [U18] | - | Club Tijuana [U18] | 4:0 | ||||
| 12. Round | 03/10/2021 | UANL Tigres [U18] | - | Club Necaxa [U18] | 1:1 | ||||
| 13. Round | 15/10/2021 | Club Necaxa [U18] | - | Puebla FC [U18] | 4:3 |
Mexico