| Round of 16 | 26/08/2021 | Deportivo Cali | - | Independiente Medellín | 2:2 |  |
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| Round of 16 | 03/09/2021 | Independiente Medellín | - | Deportivo Cali | 1:3 | ||||
| Quarter-finals | 09/09/2021 | América de Cali | - | Deportivo Cali | 2:2 |  |
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| Quarter-finals | 16/09/2021 | Deportivo Cali | - | América de Cali | 1:0 | ||||
| Semi-finals | 07/10/2021 | Deportivo Cali | - | Atlético Nacional | 2:2 | ||||
| Semi-finals | 22/10/2021 | Atlético Nacional | - | Deportivo Cali | 1:0 |
Uruguay
Italy