| 1. Round | 16/07/2022 | Sportivo Ameliano | - | Libertad | 2:0 |  |
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| 2. Round | 20/07/2022 | Libertad | - | Club Olimpia | 4:2 | ||||
| 3. Round | 24/07/2022 | General Caballero DJLM | - | Libertad | 3:2 | |
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| 4. Round | 31/07/2022 | Libertad | - | Resistencia SC | 4:0 | ||||
| 5. Round | 06/08/2022 | 12 de Octubre de Itauguá | - | Libertad | 1:3 | ||||
| 6. Round | 13/08/2022 | Libertad | - | Sol de América | 4:1 | ||||
| 7. Round | 21/08/2022 | Club Nacional | - | Libertad | 0:2 | |
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| 8. Round | 27/08/2022 | Libertad | - | Guaraní | 2:2 | ||||
| 9. Round | 04/09/2022 | Cerro Porteño | - | Libertad | 1:0 | |
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| 10. Round | 10/09/2022 | Guaireña FC | - | Libertad | 4:0 |  |
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| 12. Round | 18/09/2022 | Libertad | - | Sportivo Ameliano | 2:1 | |
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| 15. Round | 06/10/2022 | Resistencia SC | - | Libertad | 1:0 | ||||
| 16. Round | 09/10/2022 | Libertad | - | 12 de Octubre de Itauguá | 2:2 | ||||
| 13. Round | 12/10/2022 | Club Olimpia | - | Libertad | 1:0 | |
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| 17. Round | 17/10/2022 | Sol de América | - | Libertad | 1:1 | |
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| 18. Round | 23/10/2022 | Libertad | - | Club Nacional | 0:1 | ||||
| 19. Round | 27/10/2022 | Guaraní | - | Libertad | 1:2 | ||||
| 20. Round | 31/10/2022 | Libertad | - | Cerro Porteño | 0:0 | ||||
| 21. Round | 06/11/2022 | Libertad | - | Guaireña FC | 4:2 | |
Paraguay