| 1. Round | 24/07/2021 | FC Luzern | - | BSC Young Boys | 3:4 | ||||
| 2. Round | 01/08/2021 | FC St. Gallen | - | FC Luzern | 2:2 | ||||
| 3. Round | 08/08/2021 | FC Luzern | - | FC Zürich | 1:3 | ||||
| 4. Round | 22/08/2021 | Servette FC | - | FC Luzern | 4:1 | ||||
| 5. Round | 29/08/2021 | FC Luzern | - | FC Lausanne-Sport | 1:1 | ||||
| 6. Round | 11/09/2021 | FC Luzern | - | Grasshopper Club Zürich | 1:1 | ||||
| 7. Round | 23/09/2021 | FC Sion | - | FC Luzern | 1:1 | ||||
| 8. Round | 26/09/2021 | FC Luzern | - | FC Lugano | 2:3 | ||||
| 9. Round | 03/10/2021 | FC Basel 1893 | - | FC Luzern | 1:1 | ||||
| 11. Round | 24/10/2021 | FC Luzern | - | FC St. Gallen | 2:0 | ||||
| 12. Round | 31/10/2021 | FC Lausanne-Sport | - | FC Luzern | 1:1 | ||||
| 13. Round | 06/11/2021 | FC Luzern | - | FC Sion | 0:1 | ||||
| 14. Round | 21/11/2021 | FC Lugano | - | FC Luzern | 3:1 | ||||
| 16. Round | 04/12/2021 | FC Zürich | - | FC Luzern | 4:0 |
Germany
