| 1. Round | 09/01/2021 | Atlas Guadalajara | - | CF Monterrey | 0:2 | ||||
| 2. Round | 17/01/2021 | CF Monterrey | - | CF América | 1:0 | ||||
| 5. Round | 07/02/2021 | CF Monterrey | - | Pumas UNAM | 1:0 | ||||
| 6. Round | 15/02/2021 | Santos Laguna | - | CF Monterrey | 1:0 | ||||
| 7. Round | 20/02/2021 | Club Necaxa | - | CF Monterrey | 1:1 | ||||
| 8. Round | 28/02/2021 | CF Monterrey | - | Club Tijuana | 1:1 | ||||
| 9. Round | 04/03/2021 | FC Juárez | - | CF Monterrey | 1:6 | ||||
| 10. Round | 07/03/2021 | CF Monterrey | - | Gallos Blancos | 2:1 | ||||
| 3. Round | 11/03/2021 | CF Monterrey | - | Club León | 1:1 | ||||
| 11. Round | 14/03/2021 | Cruz Azul | - | CF Monterrey | 1:0 | ||||
| 13. Round | 04/04/2021 | CF Monterrey | - | Atlético San Luis | 2:0 | ||||
| 14. Round | 11/04/2021 | Deportivo Toluca | - | CF Monterrey | 1:2 | ||||
| 15. Round | 19/04/2021 | CF Monterrey | - | CF Pachuca | 0:1 | ||||
| 12. Round | 22/04/2021 | CF Monterrey | - | Deportivo Guadalajara | 1:2 | ||||
| 16. Round | 25/04/2021 | UANL Tigres | - | CF Monterrey | 2:1 | ||||
| 17. Round | 02/05/2021 | CF Monterrey | - | Mazatlán FC | 1:0 |
Mexico