| 1. Round | 18/07/2021 | Club Olimpia | - | River Plate | 1:3 | ||||
| 5. Round | 14/08/2021 | Club Olimpia | - | Cerro Porteño | 0:3 |  |
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| 6. Round | 23/08/2021 | Sportivo Luqueño | - | Club Olimpia | 2:0 | ||||
| 13. Round | 24/10/2021 | Club Olimpia | - | Guaraní | 1:3 | ||||
| 15. Round | 08/11/2021 | Club Olimpia | - | Sportivo Luqueño | 4:0 |  |
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| 16. Round | 21/11/2021 | Sol de América | - | Club Olimpia | 1:0 | ||||
| 17. Round | 26/11/2021 | Club Olimpia | - | Libertad | 2:3 | |
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| 18. Round | 05/12/2021 | Club Nacional | - | Club Olimpia | 1:3 |
Paraguay