| 1. Round | 07/08/2021 | Olympique Lyonnais B | - | AS Monaco B | 1:0 | ||||
| 2. Round | 14/08/2021 | FC Martigues | - | Olympique Lyonnais B | 1:1 |  |
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| 3. Round | 21/08/2021 | Olympique Lyonnais B | - | GFA Rumilly Vallières | 0:2 | ||||
| 7. Round | 18/09/2021 | Olympique Lyonnais B | - | Aubagne FC | 3:1 | ||||
| 8. Round | 25/09/2021 | Jura Sud | - | Olympique Lyonnais B | 1:1 | ||||
| 10. Round | 23/10/2021 | Marignane Gignac FC | - | Olympique Lyonnais B | 4:0 | ||||
| 11. Round | 06/11/2021 | Olympique Lyonnais B | - | SC Toulon | 0:0 | ||||
| 15. Round | 26/01/2022 | Lyon-La Duchère | - | Olympique Lyonnais B | 0:0 | ||||
| 26. Round | 23/04/2022 | RC Grasse | - | Olympique Lyonnais B | 2:1 | ||||
| 30. Round | 28/05/2022 | AS Monaco B | - | Olympique Lyonnais B | 4:1 |
France