| 7. Round | 27/08/2021 | Club Tijuana [U18] | - | CF Monterrey [U18] | 0:0 | ||||
| 9. Round | 16/09/2021 | Atlético San Luis [U18] | - | Club Tijuana [U18] | 1:0 | ||||
| 10. Round | 24/09/2021 | Club Tijuana [U18] | - | Mazatlán FC [U18] | 1:2 | ||||
| 11. Round | 28/09/2021 | Club Necaxa [U18] | - | Club Tijuana [U18] | 4:0 | ||||
| 12. Round | 03/10/2021 | Club Tijuana [U18] | - | Cruz Azul [U18] | 3:2 | ||||
| 13. Round | 14/10/2021 | Gallos Blancos [U18] | - | Club Tijuana [U18] | 2:0 | ||||
| 14. Round | 20/10/2021 | Club Tijuana [U18] | - | Deportivo Guadalajara [U18] | 1:3 | ||||
| 16. Round | 28/10/2021 | Atlas Guadalajara [U18] | - | Club Tijuana [U18] | 1:0 |
Mexico