 |
 |
|
| 28/10/2021 | 17:30 | Atlas Guadalajara | - | Club Tijuana | 1:0 (1:0) | |
| 29/10/2021 | 17:15 | Club Necaxa | - | Mazatlán FC | 3:0 (2:0) | |
| 18:30 | FC Juárez | - | Puebla FC | 0:2 (0:2) | ||
| 30/10/2021 | 15:00 | CF Pachuca | - | Pumas UNAM | 1:0 (0:0) | |
| 15:30 | UANL Tigres | - | Deportivo Guadalajara | 1:3 (1:0) | ||
| 17:30 | Gallos Blancos | - | Santos Laguna | 1:1 (0:1) | ||
| 31/10/2021 | 17:30 | Cruz Azul | - | CF América | 0:0 (0:0) | |
| 17:30 | Deportivo Toluca | - | Club León | 1:3 (1:3) | ||
| 17:45 | Atlético San Luis | - | CF Monterrey | 3:1 (2:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Necaxa | 16 | 12 | 3 | 1 | 44:24 | 20 | 39 |
| 2 |
|
Club León | 16 | 10 | 3 | 3 | 29:23 | 6 | 33 |
| 3 |
|
CF América | 16 | 9 | 4 | 3 | 29:18 | 11 | 31 |
| 4 |
|
CF Pachuca | 16 | 9 | 3 | 4 | 35:16 | 19 | 30 |
| 5 |
|
UANL Tigres | 16 | 8 | 5 | 3 | 29:16 | 13 | 29 |
| 6 |
|
Atlas Guadalajara | 16 | 8 | 4 | 4 | 27:20 | 7 | 28 |
| 7 |
|
Mazatlán FC | 16 | 8 | 4 | 4 | 24:21 | 3 | 28 |
| 8 |
|
Santos Laguna | 16 | 7 | 4 | 5 | 23:18 | 5 | 25 |
| 9 |
|
Deportivo Guadalajara | 16 | 6 | 6 | 4 | 31:25 | 6 | 24 |
| 10 |
|
Gallos Blancos | 16 | 5 | 6 | 5 | 13:13 | 0 | 21 |
| 11 |
|
Atlético San Luis | 16 | 5 | 4 | 7 | 25:35 | -10 | 19 |
| 12 |
|
Club Tijuana | 16 | 5 | 2 | 9 | 22:28 | -6 | 17 |
| 13 |
|
Deportivo Toluca | 16 | 4 | 4 | 8 | 20:25 | -5 | 16 |
| 14 |
|
FC Juárez | 16 | 4 | 3 | 9 | 22:27 | -5 | 15 |
| 15 |
|
Cruz Azul | 16 | 3 | 5 | 8 | 17:32 | -15 | 14 |
| 16 |
|
Puebla FC | 16 | 3 | 3 | 10 | 22:37 | -15 | 12 |
| 17 |
|
Pumas UNAM | 16 | 2 | 5 | 9 | 15:29 | -14 | 11 |
| 18 |
|
CF Monterrey | 16 | 0 | 4 | 12 | 10:30 | -20 | 4 |
| Playoffs |
