| 1. Round | 24/07/2021 | CF Pachuca [U18] | - | Club León [U18] | 5:1 |  |
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| 3. Round | 05/08/2021 | Gallos Blancos [U18] | - | Club León [U18] | 0:1 | ||||
| 7. Round | 28/08/2021 | Club León [U18] | - | CF América [U18] | 0:1 | ||||
| 10. Round | 25/09/2021 | Atlas Guadalajara [U18] | - | Club León [U18] | 2:3 | ||||
| 14. Round | 20/10/2021 | Club León [U18] | - | Pumas UNAM [U18] | 2:1 | ||||
| 16. Round | 31/10/2021 | Deportivo Toluca [U18] | - | Club León [U18] | 1:3 | |
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| 11. Round | 03/11/2021 | Cruz Azul [U18] | - | Club León [U18] | 2:3 |
Mexico