1. Round | 19/07/2021 | Libertad | - | Guaireña FC | 0:0 | ||||
3. Round | 02/08/2021 | Club Olimpia | - | Guaireña FC | 0:2 | ||||
8. Round | 12/09/2021 | Guaraní | - | Guaireña FC | 3:0 | ||||
10. Round | 27/09/2021 | Guaireña FC | - | Libertad | 2:1 | ||||
11. Round | 03/10/2021 | River Plate | - | Guaireña FC | 1:1 | ||||
15. Round | 08/11/2021 | Guaireña FC | - | Club Nacional | 0:0 | ||||
16. Round | 19/11/2021 | 12 de Octubre de Itauguá | - | Guaireña FC | 0:0 | ||||
17. Round | 28/11/2021 | Guaireña FC | - | Guaraní | 1:1 | ||||
18. Round | 04/12/2021 | Sportivo Luqueño | - | Guaireña FC | 0:1 |