| 1. Round | 07/01/2022 | Puebla FC [U18] | - | CF América [U18] | 0:1 dec. | ||||
| 3. Round | 22/01/2022 | CF América [U18] | - | Atlas Guadalajara [U18] | 0:0 | ||||
| 4. Round | 05/02/2022 | CF América [U18] | - | Atlético San Luis [U18] | 3:1 | ||||
| 5. Round | 12/02/2022 | Santos Laguna [U18] | - | CF América [U18] | 2:2 | ||||
| 2. Round | 16/02/2022 | Mazatlán FC [U18] | - | CF América [U18] | 0:3 |  |
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| 6. Round | 20/02/2022 | CF América [U18] | - | CF Pachuca [U18] | 3:0 | ||||
| 7. Round | 26/02/2022 | Pumas UNAM [U18] | - | CF América [U18] | 0:1 | ||||
| 8. Round | 01/03/2022 | CF América [U18] | - | Gallos Blancos [U18] | 1:0 | ||||
| 9. Round | 05/03/2022 | CF Monterrey [U18] | - | CF América [U18] | 3:5 | ||||
| 10. Round | 12/03/2022 | Deportivo Guadalajara [U18] | - | CF América [U18] | 3:2 | ||||
| 11. Round | 20/03/2022 | CF América [U18] | - | Deportivo Toluca [U18] | 3:2 | ||||
| 13. Round | 09/04/2022 | CF América [U18] | - | FC Juárez [U18] | 3:0 | ||||
| 15. Round | 20/04/2022 | CF América [U18] | - | Club León [U18] | 5:1 |  |
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| 16. Round | 23/04/2022 | UANL Tigres [U18] | - | CF América [U18] | 0:2 | |
Mexico