| 2. Round | 23/07/2021 | FK Ryazan | - | Salyut Belgorod | 0:4 | ||||
| 5. Round | 15/08/2021 | Avangard Kursk | - | FK Ryazan | 0:3 | ||||
| 8. Round | 04/09/2021 | FK Kaluga | - | FK Ryazan | 0:2 | ||||
| 11. Round | 18/09/2021 | FK Ryazan | - | Fakel Voronezh 2 | 1:1 | ||||
| 12. Round | 26/09/2021 | Fakel Voronezh 2 | - | FK Ryazan | 0:3 | ||||
| 13. Round | 30/09/2021 | FK Ryazan | - | Arsenal Tula 2 | 1:0 | ||||
| 14. Round | 04/10/2021 | Salyut Belgorod | - | FK Ryazan | 1:0 | ||||
| 17. Round | 19/10/2021 | FK Ryazan | - | Avangard Kursk | 1:0 | ||||
| 18. Round | 25/10/2021 | FK Ryazan | - | Zenit Penza | 3:1 | ||||
| 20. Round | 04/11/2021 | FK Ryazan | - | FK Kaluga | 2:0 | ||||
| 22. Round | 14/11/2021 | Sokol Saratov | - | FK Ryazan | 2:1 |
Russia