| 1. Round | 11/07/2021 | Metallurg Lipetsk | - | FK Tom Tomsk | 3:2 | ||||
| 2. Round | 17/07/2021 | FK Orenburg | - | Metallurg Lipetsk | 4:0 | ||||
| 3. Round | 25/07/2021 | Metallurg Lipetsk | - | Akron Tolyatti | 2:2 | ||||
| 9. Round | 05/09/2021 | Metallurg Lipetsk | - | Enisey Krasnoyarsk | 0:2 | ||||
| 10. Round | 11/09/2021 | Kuban Krasnodar | - | Metallurg Lipetsk | 0:3 | ||||
| 11. Round | 15/09/2021 | Metallurg Lipetsk | - | Spartak Moskva 2 | 0:2 |  |
|||
| 12. Round | 19/09/2021 | Alania Vladikavkaz | - | Metallurg Lipetsk | 5:0 | ||||
| 14. Round | 29/09/2021 | Olimp-Dolgoprudny | - | Metallurg Lipetsk | 1:0 | ||||
| 16. Round | 09/10/2021 | Volgar Astrakhan | - | Metallurg Lipetsk | 0:2 | ||||
| 19. Round | 23/10/2021 | Fakel Voronezh | - | Metallurg Lipetsk | 3:2 |  |
|||
| 21. Round | 06/11/2021 | Akron Tolyatti | - | Metallurg Lipetsk | 2:0 |
Russia