| 4. Round | 31/01/2021 | Santos Laguna [U20] | - | CF América [U20] | 0:1 | ||||
| 5. Round | 06/02/2021 | Atlas Guadalajara [U20] | - | Santos Laguna [U20] | 0:0 | ||||
| 13. Round | 04/04/2021 | Deportivo Guadalajara [U20] | - | Santos Laguna [U20] | 5:2 | ||||
| 14. Round | 11/04/2021 | Gallos Blancos [U20] | - | Santos Laguna [U20] | 1:0 | ||||
| 15. Round | 18/04/2021 | Santos Laguna [U20] | - | Deportivo Toluca [U20] | 2:2 | ||||
| 16. Round | 26/04/2021 | CF Pachuca [U20] | - | Santos Laguna [U20] | 3:1 | ||||
| 17. Round | 02/05/2021 | Santos Laguna [U20] | - | Puebla FC [U20] | 2:3 |
Mexico