| 1. Round | 09/01/2022 | Deportivo Guadalajara [U18] | - | Mazatlán FC [U18] | 4:1 | ||||
| 2. Round | 16/01/2022 | CF Pachuca [U18] | - | Deportivo Guadalajara [U18] | 4:2 | ||||
| 3. Round | 22/01/2022 | Deportivo Guadalajara [U18] | - | Gallos Blancos [U18] | 1:0 | ||||
| 5. Round | 12/02/2022 | Deportivo Guadalajara [U18] | - | UANL Tigres [U18] | 3:0 | ||||
| 7. Round | 26/02/2022 | Deportivo Guadalajara [U18] | - | Puebla FC [U18] | 3:0 | ||||
| 8. Round | 02/03/2022 | Atlético San Luis [U18] | - | Deportivo Guadalajara [U18] | 1:2 |  |
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| 9. Round | 05/03/2022 | Deportivo Guadalajara [U18] | - | Santos Laguna [U18] | 1:1 | ||||
| 10. Round | 12/03/2022 | Deportivo Guadalajara [U18] | - | CF América [U18] | 3:2 | ||||
| 11. Round | 20/03/2022 | Atlas Guadalajara [U18] | - | Deportivo Guadalajara [U18] | 0:0 | ||||
| 4. Round | 29/03/2022 | FC Juárez [U18] | - | Deportivo Guadalajara [U18] | 1:1 | ||||
| 12. Round | 02/04/2022 | Deportivo Guadalajara [U18] | - | CF Monterrey [U18] | 4:0 | ||||
| 13. Round | 09/04/2022 | Deportivo Toluca [U18] | - | Deportivo Guadalajara [U18] | 3:3 | ||||
| 14. Round | 16/04/2022 | Cruz Azul [U18] | - | Deportivo Guadalajara [U18] | 1:0 |
Mexico