| 5. Round | 13/09/2021 | CD Lugo | - | SD Huesca | 3:2 | ||||
| 6. Round | 19/09/2021 | SD Huesca | - | CF Fuenlabrada | 0:0 |  |
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| 7. Round | 24/09/2021 | Real Sociedad B | - | SD Huesca | 0:2 |  |
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| 8. Round | 02/10/2021 | SD Huesca | - | CD Tenerife | 1:2 | ||||
| 9. Round | 11/10/2021 | Real Zaragoza | - | SD Huesca | 0:0 | |
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| 10. Round | 16/10/2021 | Girona FC | - | SD Huesca | 1:3 | ||||
| 12. Round | 24/10/2021 | Burgos CF | - | SD Huesca | 3:1 | ||||
| 13. Round | 30/10/2021 | SD Huesca | - | SD Amorebieta | 1:1 | ||||
| 14. Round | 02/11/2021 | SD Ponferradina | - | SD Huesca | 1:1 | ||||
| 15. Round | 05/11/2021 | SD Huesca | - | CD Leganés | 0:2 | ||||
| 18. Round | 27/11/2021 | UD Almería | - | SD Huesca | 0:0 | ||||
| 20. Round | 10/12/2021 | Sporting Gijón | - | SD Huesca | 1:1 | ||||
| 21. Round | 19/12/2021 | SD Huesca | - | AD Alcorcón | 0:0 | ||||
| 22. Round | 02/01/2022 | SD Huesca | - | Girona FC | 0:1 |
Paraguay