| 1. Round | 20/07/2021 | FC Juárez [Women] | - | Cruz Azul [Women] | 0:1 | ||||
| 2. Round | 24/07/2021 | Cruz Azul [Women] | - | Deportivo Guadalajara [Women] | 1:1 | ||||
| 3. Round | 01/08/2021 | CF Pachuca [Women] | - | Cruz Azul [Women] | 0:1 | ||||
| 4. Round | 07/08/2021 | Cruz Azul [Women] | - | Pumas UNAM [Women] | 1:1 | ||||
| 5. Round | 15/08/2021 | Puebla FC [Women] | - | Cruz Azul [Women] | 3:0 | ||||
| 8. Round | 04/09/2021 | Cruz Azul [Women] | - | Atlético San Luis [Women] | 2:0 | ||||
| 9. Round | 11/09/2021 | Cruz Azul [Women] | - | Deportivo Toluca [Women] | 2:1 | ||||
| 10. Round | 26/09/2021 | Atlas Guadalajara [Women] | - | Cruz Azul [Women] | 3:0 | ||||
| 11. Round | 05/10/2021 | CF América [Women] | - | Cruz Azul [Women] | 2:1 | ||||
| 12. Round | 09/10/2021 | Cruz Azul [Women] | - | Club León [Women] | 0:0 | ||||
| 13. Round | 16/10/2021 | Cruz Azul [Women] | - | Mazatlán FC [Women] | 2:0 |  |
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| 14. Round | 29/10/2021 | Gallos Blancos [Women] | - | Cruz Azul [Women] | 1:2 | ||||
| 15. Round | 06/11/2021 | Cruz Azul [Women] | - | Club Necaxa [Women] | 1:0 | ||||
| 16. Round | 16/11/2021 | Club Tijuana [Women] | - | Cruz Azul [Women] | 4:1 | ||||
| 17. Round | 20/11/2021 | CF Monterrey [Women] | - | Cruz Azul [Women] | 5:0 | |
Mexico