| 1. Round | 20/07/2021 | Deportivo Guadalajara [Women] | - | Atlético San Luis [Women] | 5:0 | ||||
| 2. Round | 25/07/2021 | Atlético San Luis [Women] | - | Pumas UNAM [Women] | 2:1 | ||||
| 3. Round | 31/07/2021 | Deportivo Toluca [Women] | - | Atlético San Luis [Women] | 1:0 |  |
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| 4. Round | 08/08/2021 | Atlético San Luis [Women] | - | CF Pachuca [Women] | 1:1 | ||||
| 6. Round | 24/08/2021 | CF América [Women] | - | Atlético San Luis [Women] | 4:0 | ||||
| 7. Round | 29/08/2021 | Atlético San Luis [Women] | - | Club Tijuana [Women] | 1:3 | ||||
| 8. Round | 04/09/2021 | Cruz Azul [Women] | - | Atlético San Luis [Women] | 2:0 | ||||
| 13. Round | 17/10/2021 | Puebla FC [Women] | - | Atlético San Luis [Women] | 1:1 | ||||
| 14. Round | 02/11/2021 | Santos Laguna [Women] | - | Atlético San Luis [Women] | 3:1 | ||||
| 15. Round | 07/11/2021 | Atlético San Luis [Women] | - | CF Monterrey [Women] | 0:3 | ||||
| 16. Round | 13/11/2021 | Club León [Women] | - | Atlético San Luis [Women] | 0:0 | ||||
| 17. Round | 21/11/2021 | Atlético San Luis [Women] | - | Club Necaxa [Women] | 1:1 |
Mexico