| 1. Round | 08/01/2022 | FC Juárez | - | Club Necaxa | 2:1 |  |
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| 2. Round | 16/01/2022 | Cruz Azul | - | FC Juárez | 1:0 | ||||
| 3. Round | 21/01/2022 | Atlético San Luis | - | FC Juárez | 0:1 | ||||
| 9. Round | 05/03/2022 | FC Juárez | - | Club León | 0:1 | ||||
| 10. Round | 12/03/2022 | FC Juárez | - | Atlas Guadalajara | 1:2 | ||||
| 5. Round | 16/03/2022 | CF Monterrey | - | FC Juárez | 3:0 | ||||
| 15. Round | 20/04/2022 | Deportivo Toluca | - | FC Juárez | 0:1 | ||||
| 17. Round | 30/04/2022 | Gallos Blancos | - | FC Juárez | 4:0 |
Mexico