| Group C | 22/10/2020 | Hapoel Be'er Sheva | - | Slavia Praha | 3:1 | ||||
| Group C | 29/10/2020 | Slavia Praha | - | Bayer Leverkusen | 1:0 | ||||
| Group C | 26/11/2020 | OGC Nice | - | Slavia Praha | 1:3 |  |
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| Group C | 03/12/2020 | Slavia Praha | - | Hapoel Be'er Sheva | 3:0 | ||||
| Group C | 10/12/2020 | Bayer Leverkusen | - | Slavia Praha | 4:0 | ||||
| Round of 32 | 18/02/2021 | Slavia Praha | - | Leicester City | 0:0 | |
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| Round of 32 | 25/02/2021 | Leicester City | - | Slavia Praha | 0:2 | ||||
| Round of 16 | 11/03/2021 | Slavia Praha | - | Rangers FC | 1:1 | ||||
| Round of 16 | 18/03/2021 | Rangers FC | - | Slavia Praha | 0:2 | ||||
| Quarter-finals | 08/04/2021 | Arsenal FC | - | Slavia Praha | 1:1 | ||||
| Quarter-finals | 15/04/2021 | Slavia Praha | - | Arsenal FC | 0:4 |
Czech Republic