| 4. Round | 15/08/2021 | FK Teplice | - | FK Jablonec | 1:0 |  |
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| 5. Round | 21/08/2021 | FK Mladá Boleslav | - | FK Teplice | 3:1 | ||||
| 6. Round | 29/08/2021 | Bohemians Praha 1905 | - | FK Teplice | 4:2 | ||||
| 7. Round | 11/09/2021 | FK Teplice | - | Baník Ostrava | 1:2 | ||||
| 8. Round | 19/09/2021 | MFK Karviná | - | FK Teplice | 1:1 | |
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| 9. Round | 26/09/2021 | FK Teplice | - | Sigma Olomouc | 0:0 | ||||
| 10. Round | 02/10/2021 | 1. FC Slovácko | - | FK Teplice | 3:2 |
Czech Republic