| 3. Round | 14/08/2010 | RSC Anderlecht | - | Germinal Beerschot | 4:0 |  |
|||
| 5. Round | 28/08/2010 | RSC Anderlecht | - | SV Zulte Waregem | 0:0 |  |
|||
| 6. Round | 10/09/2010 | Sint-Truidense VV | - | RSC Anderlecht | 0:2 | ||||
| 7. Round | 19/09/2010 | RSC Anderlecht | - | KV Kortrijk | 3:0 | ||||
| 9. Round | 26/09/2010 | RSC Anderlecht | - | KV Mechelen | 5:0 | ||||
| 10. Round | 03/10/2010 | Standard Liège | - | RSC Anderlecht | 5:1 | ||||
| 12. Round | 24/10/2010 | RSC Anderlecht | - | KVC Westerlo | 2:0 |  |
|||
| 15. Round | 14/11/2010 | KAA Gent | - | RSC Anderlecht | 1:2 | ||||
| 16. Round | 20/11/2010 | Germinal Beerschot | - | RSC Anderlecht | 0:1 | ||||
| 17. Round | 27/11/2010 | RSC Anderlecht | - | Sporting Charleroi | 4:1 | ||||
| 18. Round | 05/12/2010 | SV Zulte Waregem | - | RSC Anderlecht | 1:2 | |
|||
| 19. Round | 12/12/2010 | RSC Anderlecht | - | Sporting Lokeren | 0:0 | ||||
| 22. Round | 29/12/2010 | KV Kortrijk | - | RSC Anderlecht | 0:2 | |
|||
| 23. Round | 23/01/2011 | RSC Anderlecht | - | Standard Liège | 2:0 | ||||
| 24. Round | 30/01/2011 | KV Mechelen | - | RSC Anderlecht | 0:0 |
Czech Republic