| 1. Round | 20/07/2021 | UANL Tigres [Women] | - | Mazatlán FC [Women] | 2:0 |  |
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| 2. Round | 27/07/2021 | Club León [Women] | - | UANL Tigres [Women] | 0:2 | ||||
| 3. Round | 03/08/2021 | UANL Tigres [Women] | - | Club Necaxa [Women] | 8:1 | |
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| 5. Round | 17/08/2021 | UANL Tigres [Women] | - | Atlético San Luis [Women] | 5:1 | ||||
| 6. Round | 21/08/2021 | Cruz Azul [Women] | - | UANL Tigres [Women] | 0:3 | ||||
| 7. Round | 31/08/2021 | UANL Tigres [Women] | - | Deportivo Toluca [Women] | 4:0 | ||||
| 8. Round | 03/09/2021 | Gallos Blancos [Women] | - | UANL Tigres [Women] | 1:2 | ||||
| 10. Round | 28/09/2021 | UANL Tigres [Women] | - | Club Tijuana [Women] | 3:0 | ||||
| 11. Round | 03/10/2021 | Puebla FC [Women] | - | UANL Tigres [Women] | 0:3 | ||||
| 12. Round | 10/10/2021 | UANL Tigres [Women] | - | CF Monterrey [Women] | 2:1 | ||||
| 13. Round | 19/10/2021 | Deportivo Guadalajara [Women] | - | UANL Tigres [Women] | 1:1 | ||||
| 14. Round | 02/11/2021 | UANL Tigres [Women] | - | FC Juárez [Women] | 3:0 | ||||
| 16. Round | 14/11/2021 | CF América [Women] | - | UANL Tigres [Women] | 1:1 | ||||
| 17. Round | 22/11/2021 | Santos Laguna [Women] | - | UANL Tigres [Women] | 0:2 |
Mexico