| 1. Round | 09/01/2021 | Atlas Guadalajara | - | CF Monterrey | 0:2 | ||||
| 2. Round | 18/01/2021 | Gallos Blancos | - | Atlas Guadalajara | 1:0 | ||||
| 3. Round | 24/01/2021 | Atlas Guadalajara | - | UANL Tigres | 0:2 |  |
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| 4. Round | 31/01/2021 | Pumas UNAM | - | Atlas Guadalajara | 0:0 | ||||
| 5. Round | 06/02/2021 | Atlas Guadalajara | - | Santos Laguna | 1:1 | ||||
| 7. Round | 21/02/2021 | Atlas Guadalajara | - | CF América | 3:0 dec. | ||||
| 8. Round | 27/02/2021 | Deportivo Toluca | - | Atlas Guadalajara | 0:0 | ||||
| 9. Round | 02/03/2021 | Atlas Guadalajara | - | Atlético San Luis | 3:1 |  |
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| 13. Round | 04/04/2021 | Atlas Guadalajara | - | Club Tijuana | 1:0 | ||||
| 14. Round | 10/04/2021 | Atlas Guadalajara | - | Club León | 1:3 | |
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| 16. Round | 25/04/2021 | Atlas Guadalajara | - | Deportivo Guadalajara | 0:1 |
Argentina