1. Round | 08/08/2021 | CD Tondela | - | CD Santa Clara | 3:0 | ||||
2. Round | 15/08/2021 | CD Santa Clara | - | Moreirense FC | 2:2 | ||||
3. Round | 23/08/2021 | Boavista | - | CD Santa Clara | 2:0 | ||||
4. Round | 29/08/2021 | CD Santa Clara | - | Gil Vicente | 1:0 | ||||
5. Round | 11/09/2021 | CD Santa Clara | - | SL Benfica | 0:5 | ||||
6. Round | 17/09/2021 | Portimonense SC | - | CD Santa Clara | 2:1 | ||||
7. Round | 26/09/2021 | CD Santa Clara | - | Sporting Braga | 1:1 | ||||
8. Round | 02/10/2021 | FC Vizela | - | CD Santa Clara | 1:1 | ||||
9. Round | 23/10/2021 | CD Santa Clara | - | FC Famalicão | 0:2 | ||||
10. Round | 31/10/2021 | Belenenses SAD | - | CD Santa Clara | 2:1 | ||||
11. Round | 07/11/2021 | CD Santa Clara | - | FC Porto | 0:3 | ||||
12. Round | 29/11/2021 | GD Estoril | - | CD Santa Clara | 2:2 | ||||
13. Round | 05/12/2021 | CD Santa Clara | - | FC Arouca | 2:1 | ||||
14. Round | 11/12/2021 | CS Marítimo | - | CD Santa Clara | 4:1 | ||||
15. Round | 17/12/2021 | CD Santa Clara | - | Vitória Guimarães | 1:0 | ||||
17. Round | 07/01/2022 | CD Santa Clara | - | Sporting CP | 3:2 |