| 22. Round | 17/08/2022 | El Nacional | - | Atlético Santo Domingo | 0:0 | ||||
| 30. Round | 28/09/2022 | Atlético Santo Domingo | - | El Nacional | 1:2 | ||||
| 32. Round | 05/10/2022 | Atlético Santo Domingo | - | Imbabura | 1:0 | ||||
| 33. Round | 13/10/2022 | Olmedo | - | Atlético Santo Domingo | 2:1 |  |
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| 35. Round | 25/10/2022 | Atlético Santo Domingo | - | Manta | 2:0 | |
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| 36. Round | 30/10/2022 | Búhos ULVR | - | Atlético Santo Domingo | 1:1 |
Ecuador