| 1. Round | 10/01/2021 | Deportivo Toluca | - | Gallos Blancos | 3:1 | ||||
| 4. Round | 31/01/2021 | Cruz Azul | - | Gallos Blancos | 4:1 | ||||
| 5. Round | 05/02/2021 | Gallos Blancos | - | CF Pachuca | 3:1 | ||||
| 6. Round | 14/02/2021 | CF América | - | Gallos Blancos | 2:1 | ||||
| 7. Round | 21/02/2021 | Gallos Blancos | - | Puebla FC | 1:1 | ||||
| 8. Round | 27/02/2021 | Mazatlán FC | - | Gallos Blancos | 3:0 | ||||
| 9. Round | 04/03/2021 | Gallos Blancos | - | Deportivo Guadalajara | 2:2 | ||||
| 10. Round | 07/03/2021 | CF Monterrey | - | Gallos Blancos | 2:1 |  |
|||
| 11. Round | 15/03/2021 | Gallos Blancos | - | Atlético San Luis | 2:1 | |
|||
| 12. Round | 21/03/2021 | Club Tijuana | - | Gallos Blancos | 3:1 | ||||
| 16. Round | 26/04/2021 | Gallos Blancos | - | FC Juárez | 1:0 | ||||
| 17. Round | 01/05/2021 | Club León | - | Gallos Blancos | 2:1 |
Ecuador