| 1. Round | 06/08/2021 | FC Dordrecht | - | Jong PSV | 1:1 | ||||
| 2. Round | 16/08/2021 | Jong PSV | - | FC Den Bosch | 0:1 | ||||
| 3. Round | 23/08/2021 | Jong PSV | - | FC Eindhoven | 3:2 | ||||
| 4. Round | 27/08/2021 | Helmond Sport | - | Jong PSV | 1:0 |  |
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| 6. Round | 10/09/2021 | Jong PSV | - | Jong Ajax | 3:1 | ||||
| 5. Round | 13/09/2021 | FC Utrecht (J) | - | Jong PSV | 2:1 | ||||
| 7. Round | 20/09/2021 | Jong PSV | - | ADO Den Haag | 0:1 | ||||
| 8. Round | 24/09/2021 | SBV Excelsior | - | Jong PSV | 3:0 | ||||
| 16. Round | 19/11/2021 | FC Emmen | - | Jong PSV | 2:0 | ||||
| 15. Round | 22/11/2021 | Jong PSV | - | NAC Breda | 0:0 | |
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| 17. Round | 26/11/2021 | MVV | - | Jong PSV | 1:2 | ||||
| 18. Round | 06/12/2021 | Jong PSV | - | De Graafschap | 2:3 | ||||
| 19. Round | 10/12/2021 | FC Volendam | - | Jong PSV | 3:2 | ||||
| 20. Round | 17/12/2021 | Telstar | - | Jong PSV | 0:0 | ||||
| 26. Round | 14/02/2022 | Jong PSV | - | FC Utrecht (J) | 0:2 | ||||
| 28. Round | 25/02/2022 | NAC Breda | - | Jong PSV | 3:1 |  |
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| 29. Round | 07/03/2022 | Jong PSV | - | FC Emmen | 1:3 | ||||
| 27. Round | 14/03/2022 | FC Den Bosch | - | Jong PSV | 3:2 | ||||
| 31. Round | 18/03/2022 | Jong PSV | - | Roda JC Kerkrade | 3:3 |
Netherlands