| 2. Round | 15/08/2022 | Jong PSV | - | FC Dordrecht | 1:0 | ||||
| 3. Round | 22/08/2022 | Jong PSV | - | Heracles Almelo | 0:3 |  |
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| 4. Round | 26/08/2022 | PEC Zwolle | - | Jong PSV | 4:2 | ||||
| 5. Round | 05/09/2022 | Jong PSV | - | TOP Oss | 0:3 | ||||
| 6. Round | 09/09/2022 | Roda JC Kerkrade | - | Jong PSV | 1:1 | ||||
| 8. Round | 12/09/2022 | Jong PSV | - | FC Den Bosch | 3:1 |  |
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| 7. Round | 16/09/2022 | VVV-Venlo | - | Jong PSV | 1:1 | ||||
| 9. Round | 30/09/2022 | ADO Den Haag | - | Jong PSV | 1:3 | ||||
| 10. Round | 07/10/2022 | Jong PSV | - | Telstar | 0:2 | |
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| 11. Round | 14/10/2022 | MVV | - | Jong PSV | 1:1 | ||||
| 14. Round | 07/11/2022 | Jong PSV | - | Almere City FC | 0:1 | ||||
| 15. Round | 11/11/2022 | De Graafschap | - | Jong PSV | 3:2 | ||||
| 16. Round | 17/11/2022 | Jong PSV | - | FC Utrecht (J) | 2:1 | |
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| 17. Round | 12/12/2022 | AZ Alkmaar (J) | - | Jong PSV | 2:3 | ||||
| 18. Round | 15/12/2022 | Jong PSV | - | Jong Ajax | 2:2 | ||||
| 19. Round | 06/01/2023 | NAC Breda | - | Jong PSV | 2:1 | |
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| 21. Round | 20/01/2023 | FC Den Bosch | - | Jong PSV | 1:0 | |
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| 22. Round | 30/01/2023 | Jong PSV | - | Willem II | 3:2 |
Netherlands