| 1. Round | 09/01/2021 | Club Tijuana | - | Pumas UNAM | 0:0 | ||||
| 2. Round | 17/01/2021 | Pumas UNAM | - | Mazatlán FC | 3:0 | ||||
| 3. Round | 25/01/2021 | Gallos Blancos | - | Pumas UNAM | 2:0 | ||||
| 4. Round | 31/01/2021 | Pumas UNAM | - | Atlas Guadalajara | 0:0 |  |
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| 5. Round | 07/02/2021 | CF Monterrey | - | Pumas UNAM | 1:0 | ||||
| 6. Round | 14/02/2021 | Deportivo Toluca | - | Pumas UNAM | 1:0 | ||||
| 7. Round | 21/02/2021 | Pumas UNAM | - | Club León | 0:1 | ||||
| 9. Round | 05/03/2021 | Pumas UNAM | - | Santos Laguna | 1:0 | |
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| 10. Round | 08/03/2021 | Pumas UNAM | - | Cruz Azul | 0:1 | ||||
| 11. Round | 13/03/2021 | FC Juárez | - | Pumas UNAM | 1:1 | ||||
| 12. Round | 20/03/2021 | Atlético San Luis | - | Pumas UNAM | 0:1 | ||||
| 13. Round | 04/04/2021 | Pumas UNAM | - | CF Pachuca | 2:2 | ||||
| 17. Round | 03/05/2021 | Pumas UNAM | - | CF América | 0:1 |
Mexico