| 1. Round | 11/01/2022 | Pumas UNAM | - | Deportivo Toluca | 5:0 | ||||
| 2. Round | 15/01/2022 | Gallos Blancos | - | Pumas UNAM | 1:3 | ||||
| 3. Round | 23/01/2022 | Pumas UNAM | - | UANL Tigres | 1:2 |  |
|||
| 5. Round | 13/02/2022 | Pumas UNAM | - | Club León | 2:1 | ||||
| 6. Round | 21/02/2022 | Atlas Guadalajara | - | Pumas UNAM | 0:0 | ||||
| 7. Round | 27/02/2022 | Pumas UNAM | - | CF América | 0:0 | ||||
| 10. Round | 13/03/2022 | Cruz Azul | - | Pumas UNAM | 2:1 | ||||
| 11. Round | 19/03/2022 | Pumas UNAM | - | Club Necaxa | 1:3 | ||||
| 9. Round | 26/03/2022 | Pumas UNAM | - | Mazatlán FC | 1:1 | ||||
| 12. Round | 03/04/2022 | FC Juárez | - | Pumas UNAM | 0:1 |
Mexico