| 4. Round | 17/08/2021 | Mineros de Zacatecas | - | Pumas Tabasco | 1:2 |  |
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| 5. Round | 25/08/2021 | Pumas Tabasco | - | Dorados de Sinaloa | 0:2 | ||||
| 6. Round | 02/09/2021 | Club Celaya | - | Pumas Tabasco | 1:2 | ||||
| 7. Round | 09/09/2021 | Pumas Tabasco | - | Atlante | 0:2 | ||||
| 8. Round | 15/09/2021 | Correcaminos UAT | - | Pumas Tabasco | 0:2 | ||||
| 9. Round | 23/09/2021 | Pumas Tabasco | - | Venados FC | 1:1 | ||||
| 10. Round | 01/10/2021 | Cimarrones de Sonora | - | Pumas Tabasco | 2:1 | |
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| 11. Round | 07/10/2021 | Pumas Tabasco | - | Leones Negros | 1:1 | ||||
| 14. Round | 29/10/2021 | Atlético Morelia | - | Pumas Tabasco | 0:1 | ||||
| 15. Round | 07/11/2021 | CF Monterrey II | - | Pumas Tabasco | 1:1 |  |
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| 17. Round | 17/11/2021 | TM Fútbol Club | - | Pumas Tabasco | 1:1 |
Mexico