| 1. Round | 24/07/2021 | Deportivo Guadalajara [U18] | - | Atlético San Luis [U18] | 6:0 | ||||
| 2. Round | 02/08/2021 | Atlético San Luis [U18] | - | Gallos Blancos [U18] | 1:0 |  |
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| 3. Round | 08/08/2021 | Pumas UNAM [U18] | - | Atlético San Luis [U18] | 1:1 | ||||
| 4. Round | 12/08/2021 | Atlético San Luis [U18] | - | Club Necaxa [U18] | 3:3 | ||||
| 6. Round | 21/08/2021 | Atlético San Luis [U18] | - | Cruz Azul [U18] | 2:3 | ||||
| 7. Round | 27/08/2021 | Mazatlán FC [U18] | - | Atlético San Luis [U18] | 5:1 | ||||
| 13. Round | 16/10/2021 | Atlético San Luis [U18] | - | CF América [U18] | 1:1 | ||||
| 15. Round | 24/10/2021 | Atlético San Luis [U18] | - | Atlas Guadalajara [U18] | 0:1 | ||||
| 16. Round | 31/10/2021 | Atlético San Luis [U18] | - | CF Monterrey [U18] | 3:1 | ||||
| 5. Round | 03/11/2021 | CF Pachuca [U18] | - | Atlético San Luis [U18] | 3:2 | ||||
| 17. Round | 07/11/2021 | Santos Laguna [U18] | - | Atlético San Luis [U18] | 6:1 |
Mexico