| 1. Round | 22/07/2021 | Gallos Blancos [U20] | - | CF América [U20] | 0:1 | ||||
| 2. Round | 02/08/2021 | Atlético San Luis [U20] | - | Gallos Blancos [U20] | 0:2 |  |
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| 3. Round | 05/08/2021 | Gallos Blancos [U20] | - | Club León [U20] | 1:0 | ||||
| 4. Round | 14/08/2021 | Pumas UNAM [U20] | - | Gallos Blancos [U20] | 1:4 | ||||
| 6. Round | 22/08/2021 | Gallos Blancos [U20] | - | CF Pachuca [U20] | 1:2 | ||||
| 7. Round | 27/08/2021 | Puebla FC [U20] | - | Gallos Blancos [U20] | 0:1 | ||||
| 8. Round | 12/09/2021 | Gallos Blancos [U20] | - | Club Necaxa [U20] | 2:2 | ||||
| 9. Round | 19/09/2021 | Cruz Azul [U20] | - | Gallos Blancos [U20] | 1:1 | ||||
| 10. Round | 24/09/2021 | FC Juárez [U20] | - | Gallos Blancos [U20] | 1:1 | ||||
| 11. Round | 29/09/2021 | Gallos Blancos [U20] | - | Deportivo Guadalajara [U20] | 1:2 | ||||
| 16. Round | 30/10/2021 | Gallos Blancos [U20] | - | Santos Laguna [U20] | 0:5 | ||||
| 17. Round | 04/11/2021 | Atlas Guadalajara [U20] | - | Gallos Blancos [U20] | 1:1 |
Mexico