| 1. Round | 08/01/2022 | Cruz Azul [U18] | - | Club Tijuana [U18] | 3:2 | ||||
| 2. Round | 15/01/2022 | Club Tijuana [U18] | - | Club León [U18] | 1:2 | ||||
| 3. Round | 21/01/2022 | Puebla FC [U18] | - | Club Tijuana [U18] | 1:1 |  |
|||
| 4. Round | 05/02/2022 | Club Tijuana [U18] | - | Pumas UNAM [U18] | 2:0 | ||||
| 5. Round | 11/02/2022 | Mazatlán FC [U18] | - | Club Tijuana [U18] | 0:2 | ||||
| 7. Round | 25/02/2022 | Club Tijuana [U18] | - | Atlas Guadalajara [U18] | 3:3 | ||||
| 10. Round | 12/03/2022 | Santos Laguna [U18] | - | Club Tijuana [U18] | 4:0 | ||||
| 12. Round | 03/04/2022 | UANL Tigres [U18] | - | Club Tijuana [U18] | 2:0 | ||||
| 13. Round | 11/04/2022 | CF Pachuca [U18] | - | Club Tijuana [U18] | 1:2 | ||||
| 14. Round | 15/04/2022 | Club Tijuana [U18] | - | CF América [U18] | 2:0 | ||||
| 16. Round | 24/04/2022 | Club Tijuana [U18] | - | Gallos Blancos [U18] | 4:1 | ||||
| 17. Round | 30/04/2022 | CF Monterrey [U18] | - | Club Tijuana [U18] | 1:1 |
Mexico